protein
| activating the anaphase promoting complex (APC/C) |
|
SPATC1 |
|
interacting with HDAC6 that stimulates activity of CDC20-ANPC and drives the differentiation of neurons |
|
NEUROD2 might be a target of CDC20-ANPC in the control of presynaptic development |
|
interaction between HSF2 and the APC/C subunit CDC27 and coactivator CDC20 is enhanced by moderate heat stress, and the degradation of HSF2 is induced during the acute phase of the heat shock response |
|
specifically targets E2F1 for degradation in early mitosis and reveal a novel mechanism for limiting free E2F1 levels in cells, failure of which may compromise cell survival and/or homeostasis |
|
transcriptionally up-regulates UBE2C expression through its WD40 domain |
|
BUB1B-dependent CDC20 proteasomal degradation in G0 phase is required for ciliogenesis |
|
FBXW52 is a substrate of both PLK4 and CDC20, two established regulators of centriole duplication |
|
binds to key mitotic substrates, targeting them for ubiquitin modification by the APC/C, ultimately resulting in their degradation |
|
stable interaction of CDC20 with MAD2 is required to maintain spindle assembly checkpoint (SAC) signaling |
|
PHF8 is regulated by CDC20 and plays an important role in the G2/M transition |
|
switch from activation of the anaphase-promoting complex/cyclosome (APC/C) by CDC20 to CDH1 during anaphase is crucial for accurate mitosis |
|
CHEK1 is required for the metaphase-anaphase transition via regulating the subcellular localization and the expression of CDC20 and MAD2L1 |
|
FBXO43 inhibits APC/C-CDC20, and functions as a cytostatic factor that causes long-term M phase arrest of mature oocytes |