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FLASH GENE
Symbol GPR35 contributors: mct/npt/shn/pgu - updated : 24-03-2011
HGNC name G protein-coupled receptor 35
HGNC id 4492
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
    • HOMOLOGY
    interspecies ortholog to GPR35, GPR35
    ortholog to GPR35, Pan troglodytes
    ortholog to Gpr35, Mus musulus
    ortholog to Gpr35, Rattus norvegicus
    Homologene
    FAMILY
  • G protein-coupled receptor family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • receptor having rhodopsin-like receptor activity
  • functions as a receptor for the kynurenine pathway intermediate kynurenic acid
  • having a potential role in regulating neuronal excitability and synaptic release
  • receptor for lysophosphatidic acid
  • play an important role in immune modulation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2Q37
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    expressed in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene for brachymetaphalangism and/or obesity in the del2q37 syndrome
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetemetabolic syndrom 
    potential exploratory target for the treatment of both metabolic disorders and hypertension
    ANIMAL & CELL MODELS