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FLASH GENE
Symbol MANBA contributors: mct - updated : 27-06-2011
HGNC name mannosidase, beta A, lysosomal
HGNC id 6831
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Manba
homolog to C.elegans C33g3.4
Homologene
FAMILY
  • glycosyl hydrolase 2 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • involved in removal of N-linked mannose during glycoprotein catabolism
  • dissects the non-reducing end of N-linked mannose moieties of glycoproteins in eukaryotic cells
  • acting to degrade N-linked oligosaccharides and hence playing an important role in mannose metabolism
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    text protein deglycosylation
    PATHWAY
    metabolism other
    signaling
    glycoprotein catabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other targeted to the lysosome by M6P receptor mediated pathway
    ASSOCIATED DISORDERS
    corresponding disease(s) MANBA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS