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FLASH GENE
Symbol FFAR3 contributors: mct - updated : 14-06-2018
HGNC name free fatty acid receptor 3
HGNC id 4499
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM)
  • a glycosylation site
  • a PKC phosphorylation site
  • two PKA/PKC phoshporylation sites
  • a palmitoylation site
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Gpr41 (75.8 pc)
    homolog to murine Gpr41 (76.9 pc)
    intraspecies homolog to GPR43
    Homologene
    FAMILY G protein coupled receptor family
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as an orphan receptor involved in G-protein coupled receptor protein signaling pathway
  • having purinergic nucleotide receptor activity
  • inducing apoptosis via TP53/Bax pathway in an ischemia/reperfusion paradigm
  • acting as a receptor for short chain fatty acids through a G(i)- protein-mediated inhibition of adenylyl cyclase and elevation of intracellular calcium
  • acting as a rhodopsin-like receptor
  • mediate short-chain fatty acids signaling in mammary epithelial cells and thereby play an important role in their stress management
  • potential regulator of host energy balance through effects that are dependent upon the gut microbiota
  • its expression in colonic mucosa may function as a sensor for luminal short-chain fatty acids
  • G protein-coupled receptor activated by short chain carboxylic acids
  • might play an important role in sympathetic ganglia
  • associated with histone acetylation and might be involved in the acetylation-related regulation of cell processes including proliferation, apoptosis, and the cell cycle
  • its expression is mediated via an internal ribosome entry site located in the intergenic region of a bicistronic mRNA
  • beta cell-specific expression of the FFAR3 gene is controlled by an unusual mechanism that involves control at both the level of transcription and translation
  • play important roles not only as essential nutritional components but also as signaling molecules in numerous physiological processes
  • is involved in SCFA-dependent energy regulation, and in host energy regulation
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • short-chain fatty acids–FFAR3 interactions that regulate sympathetic nervous system could represent a central mechanism to account for the effects of diet, prebiotics, and probiotics on body homeostasis
  • FFAR3 and its ligands, short-chain fatty acids (SCFAs) may play an important role in the fine-tuning of insulin secretion in fed and fasting states
  • RGS4 appears essential for propionate/FFAR3 signaling attenuation in both cardiomyocytes and sympathetic neurons, leading to cardioprotection against inflammation/adverse remodeling and to sympatholysis, respectively
  • cell & other
  • binding to C2-C6 short chain fatty acids ligand
  • REGULATION
    activated by short chain fatty acids to stimulate leptin production in adipocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    significant lower methylation in obese and type 2 diabetics with an increase in obese patients over the intervention period
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS