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FLASH GENE
Symbol KIR2DS2 contributors: mct/npt - updated : 30-04-2010
HGNC name killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
HGNC id 6334
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two Ig extracellular domains
  • a short cytoplasmic tail
    • HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • natural killer cell receptors family
    • CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 membrane protein
    basic FUNCTION
  • may be functioning as a receptor for class I molecules on NK cells
  • may be activating NK cell activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to systemic sclerosis (SSc)
  • to systemic lupus erythematosus (Pellett 2007)
    • Variant & Polymorphism other association of the combination KIR2DS2(+)/KIR2DL2(-) with increased risk for SSc (Salim 2010)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS