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FLASH GENE
Symbol GABRE contributors: - updated : 11-02-2004
HGNC name gamma-aminobutyric acid (GABA) A receptor, epsilon
HGNC id 4085
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a ligand binding site in the N terminal region, four transmembrane segments,one of which forming the wall of the channel and a large intracellular loop
mono polymer pentamer
HOMOLOGY
interspecies homolog to murine Gabre
Homologene
FAMILY ligand gated ionic channel family
CATEGORY receptor membrane ligand ion channel
SUBCELLULAR LOCALIZATION
basic FUNCTION multisubunit chloride channel mediating the fastest inhibitory synaptic transmission in the central nervous system.
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component component of a pentameric receptor mediating inhibitory neurotransmission
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
ANIMAL & CELL MODELS