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FLASH GENE
Symbol SQLE contributors: mct - updated : 28-01-2020
HGNC name squalene epoxidase
HGNC id 11279
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • monooxygenase domain
  • FAD binding domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • squalene epoxidase catalyzing the first oxygenation step in sterol biosynthesis
  • microsomal enzyme that catalyzes the conversion of squalene to 2,3(s)-oxidosqualene, the immediate precursor to lanosterol in the cholesterol biosynthesis pathway
  • role of SQLE as a novel diagnostic parameter for oestrogen receptor-positive (ER+) early stage breast cancers
  • is an important control point in the pathway, and is regulated at the post-translational level by accelerated cholesterol-dependent ubiquitination and proteasomal degradation, which is associated with the accumulation of squalene
  • is the second rate-limiting enzyme in cholesterol biosynthesis and is regulated both transcriptionally and post-translationally
  • catalyzes the stereospecific conversion of squalene to 2,3(S)-oxidosqualene, a key step in cholesterol biosynthesis
  • is a rate-limiting enzyme in cholesterol synthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component form a complex with squalene synthase
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    FAD
    protein
  • MARCHF6 controls abundance of both SQLE and HMGCR, establishing it as a major regulator of flux through the cholesterol synthesis pathway
  • cholesterol accelerates the ubiquitination of SQLE by MARCH6, a key E3 ubiquitin ligase involved in ER-associated degradation
  • cell & other
    REGULATION
    activated by OSBPL2 deficiency that upregulates SQLE expression and increases the accumulation of cholesterol and cholesteryl ester by suppressing AMPK signalling, which provides new evidence of the connection between OSBPL2 and cholesterol synthesis
    induced by SEC14L2 (stimulates squalene monooxygenase, a downstream enzyme in the cholesterol biosynthetic pathway) )
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    indicated poor prognosis in lung lung squamous cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS