basic FUNCTION
| squalene epoxidase catalyzing the first oxygenation step in sterol biosynthesis |
|
microsomal enzyme that catalyzes the conversion of squalene to 2,3(s)-oxidosqualene, the immediate precursor to lanosterol in the cholesterol biosynthesis pathway |
|
role of SQLE as a novel diagnostic parameter for oestrogen receptor-positive (ER+) early stage breast cancers |
|
is an important control point in the pathway, and is regulated at the post-translational level by accelerated cholesterol-dependent ubiquitination and proteasomal degradation, which is associated with the accumulation of squalene |
|
is the second rate-limiting enzyme in cholesterol biosynthesis and is regulated both transcriptionally and post-translationally |
|
catalyzes the stereospecific conversion of squalene to 2,3(S)-oxidosqualene, a key step in cholesterol biosynthesis |
|
is a rate-limiting enzyme in cholesterol synthesis |