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FLASH GENE
Symbol KPNA2 contributors: mct - updated : 29-12-2018
HGNC name karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
HGNC id 6395
PROTEIN
PHYSICAL PROPERTIES Hydrophilic Hydrophobic
STRUCTURE
motifs/domains
  • 10 ARM repeats
  • one IBB domain
  • a highly basic N terminus and an acidic C terminus
    • HOMOLOGY
    interspecies homolog to rattus Kpna2 (94.7pc)
    homolog to murine Kpna2 (94.5pc)
    intraspecies paralog to QIP1
    Homologene
    FAMILY
  • importin alpha protein family
    • CATEGORY adaptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text cytoplasmic face of the nuclear pore complex (NPL) translocated to nucleus after loading protein and complexing with importin beta
    basic FUNCTION
  • may be involved in nuclear import of proteins
  • may play a role in V(D)J recombination
  • functioning in nuclear protein import as an adapter protein for nuclear receptor KPNB1
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text nuclear
    PATHWAY
    metabolism
    signaling
    a component
  • component of the NLS import receptor including an heterodimer of importin alpha and beta
  • found in a complex with CSE1L/XPO2 and RAN
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • recognizing the nuclear localization signal of nuclear proteins (NLS),such as PLAG1, DNA helicase Q1
  • interacting with POU5F1 (Li 2008)
  • TPR import was mediated by the most abundant import receptor, KPNA2, which binds the bipartite NLS in TPR with nanomolar affinity
  • nuclear import of RELA mainly relies on the canonical KPNA2/KPNB1 pathway
  • EI24 can bind specifically to KPNA2/KPNB1 to impede their normal role in nuclear import, shedding new light on the cellular functions of EI24 and its tumor suppressor role
  • interactions observed between TNRC6A and KPNA2
  • USP22 promoted nuclear translocation of IRF3 by deubiquitianting and stabilizing KPNA2 after viral infection
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS