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FLASH GENE

Symbol

MNX1

contributors: mct/npt - updated : 14-04-2015

HGNC name	motor neuron and pancreas homeobox 1
HGNC id	4979

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	polyalanine repeat region
	a highly conserved domain of unknown functions
	a helix-turn-helix, DNA binding domain
	a nuclear localization signal (NLS) within the homeobox

HOMOLOGY

interspecies	homolog to Drosophila proboscipedia (distantly)
	homolog to murine Hlxb9

Homologene

FAMILY

homeobox domain protein family (non HOX)

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	regulating gene transcription in lymphoid and pancreatic tissues
	implicated in the development of both solid and hematological malignancies
	may have a dual role in childhood leukemia, as an oncogene in infant AML but as a tumor suppressor in childhood ALL
	is an important factor for beta-cell proliferation and insulin regulation
	role for MNX1 in human pancreatic beta-cell development
	key role in development of the human pancreas

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacts with MEN1 and reduces cell proliferation and causes apoptosis in the presence of menin, and it regulates genes that modulate insulin level

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SCRA , DEL7Q36

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       fused with ETV6 in t(7;12)(q36;p13) in myeloid malignancy with poor prognosis constitutional germinal mutation       causes neonatal diabetes

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS