basic FUNCTION
| involved in the recombination repair pathway, of double-stranded DNA |
|
play an important role in the repair of DNA double-strand breaks (DSBs) by homologous recombination |
|
RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, play an essential role in the DNA repair reactions through homologous recombination |
|
RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 are key enzymes for DNA double-strand break repair |
|
functions jointly with GEN1 later in the pathway at the stage of Holliday junction resolution |
|
XRCC2 and XRCC3 complexes act at different stages of the homologous recombination (HR) pathway |
|
XRCC3 and RAD51C have been implicated in homologous recombination (HR) and DNA damage responses |
|
XRCC3 is a new player in the ATM/ATR-induced DNA damage responses to control checkpoint and HR-mediated repair |
|
plays an important role in the repair of DNA double-strand breaks |
|
likely a direct role of RAD51C/XRCC3 in maintaining mtDNA integrity under replication stress conditions |
|
RAD51B, RAD51C, RAD51D, XRCC2, XRCC3 sequentially orchestrate clinically relevant transactions at replication forks, cooperatively promoting fork remodeling and restart |
|
function of XRCC3 and other RAD51 paralogs in synergizing with RAD51 nucleoprotein filament to prevent degradation of stressed replication forks |