motifs/domains
| N terminal region containing elements required for localization of talin to cell-ECM junctions, and N-terminal talin head (47 kDa) contains a FERM domain composed of F1, F2, and F3 domains |
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a F0 subdomain is located N-terminus to F1, F0F1, and is essential for talin-induced activation of integrin alphaLbeta2 (LFA1) (  |
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calpain cleavage site at both the N- and C-terminal regions of talin contributing to the regulation of ocal adhesions dynamics |
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F2 and F3 FERM subdomains contribute to binding (F3 domain has a phosphotyrosine-binding domain-like fold and binds to both the membrane proximal NPXY motif in beta3-integrin tails and the membrane proximal helix) |
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a membrane interaction site |
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in the central region of the rod, AAs 1359–1659 show significant homology to the gene MESDC1 |
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a C-terminal calpain2 cleavage site important in focal adhesion dynamics ( |
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a C terminal region containing binding sites for vinculin, actin, integrin beta, with a five-helix bundle linked to an helix responsible for dimerization, (I/LWEQ module is a conserved structural element that is critical for I/LWEQ module protein function) |
| SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| text
| co-localizes with SYNM within the costameres of human skeletal muscle cells |
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abundant in the cytosol, however, it mediates adhesion by associating with integrins in the plasma membrane where it forms a primary link between integrins and the actin cytoskeleton |
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was concentrated in peripheral focal adhesions |
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| basic FUNCTION
| cytoskeleton protein binding to vinculin and integrin |
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concentrating at points of cell adhesion (focal contacts), also substrate for calpa |
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n II |
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is the primary link between integrins and actin in dynamic focal adhesions in undifferentiated, motile cells |
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responding and participating in reorganization of membrane-cytoplasmic interactions |
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link the actin cytoskeleton to the extracellular environment through interactions with beta-integrins and actin |
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essential to integrin activation in platelets |
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required to support coupling of surface-associated fibronectin to the actin cytoskeleton through C-terminal region |
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serves as an essential link between integrins and the actin cytoskeleton in several similar, but functionally distinct, adhesion complexes, including focal adhesions, costameres, and intercalated disks |
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provides a direct link between the integrin family of cell adhesion molecules and the actin cytoskeleton |
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through conserved dimerization motif in the I/LWEQ module, plays an essential role as a component of focal adhesions and, by extension, the other I/LWEQ module proteins in other multicomponent assemblies involved in cell adhesion and vesicle trafficking |
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TLN1, TLN2 are crucial for skeletal muscle development, where they regulate myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions (MTJs) |
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key integrin coactivator |
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not required for follicular B-cell maturation in the spleen or homeostatic humoral immunity but is critical for integrin-dependent B lymphocyte emigration to lymph nodes and optimal immunity against T-dependent antigens |
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endothelial cell TLN1 is essential for embryonic angiogenesis |
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cytoskeletal protein that binds to integrin beta cytoplasmic tails and regulates integrin activation |
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recruits and activates focal adhesion proteins required for proliferation via the C terminus of its rod domain |
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new function for talin, which is to link integrin adhesions with cell cycle progression |
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adaptor proteins that connect the integrin family of cell adhesion receptors to cytoskeletal actin |
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plays a key role in cell adhesion and spreading |
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dimeric adaptor protein that associates with the integrin family of cell adhesion molecules in cell-extracellular matrix junctions (focal adhesions) |
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TLN1 and RAP1A are critical for resorptive function, and their selective inhibition in mature osteoclasts retards pathological bone loss |
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TLN1 and TLN2 have distinct functions in the myocardium |
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is essential protein for integrin adhesion |
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would be involved in the integrin-dependent hypertrophic response of the myocardium |
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is not essential in the adult myocardium and its loss from cardiac myocytes (CMs) only leads to a mild stress response |
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appears to be critical in acute costameric force-sensing and mechanical signaling |
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actin-binding proteins TLN1 and VCL cooperate to provide the link between extracellular-matrix-bound integrins and intracellular F-actin, essential for cell spreading and migration |
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