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FLASH GENE
Symbol FOSL2 contributors: mct - updated : 17-12-2014
HGNC name FOS-like antigen 2
HGNC id 3798
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
basic leucine zipper (bZIP) protein
mono polymer heteromer , dimer
HOMOLOGY
Homologene
FAMILY Fos gene family
CATEGORY transcription factor , antigen
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • implicated as regulators of cell proliferation, differentiation, and transformation
  • controling osteoclast survival and size through LIF/LIF-receptor signalling
  • is a basic -leucine zipper (bZIP) motif 'Fos' family transcription factor that is part of the AP1 transcription factor complex and is also known to play a critical role in the progression of human tumours and more recently as a determinant of T cell plasticity
    • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component forming heterodimers, the AP-1 complex with JUN family of proteins
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • SOX4 is a direct target gene of FOSL2 and induces expression of HDAC8 in adult T-cell leukemia/lymphoma
  • FOSL2 is a novel STAT5A target gene, regulated by IL2 in activated CD4 T cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in head and neck squamous cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • potential targets for the treatment of syndromes associated with increased osteoclastogenesis
    • ANIMAL & CELL MODELS