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FLASH GENE
Symbol CTPS1 contributors: mct/ - updated : 04-09-2017
HGNC name CTP synthase 1
HGNC id 2519
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two domains, a synthetase domain and a glutamine amidotransferase (GAT) domain
  • several phosphorylation sites to the C-terminus, including the site for GSK3A and GSK3B phosphorylation
  • HOMOLOGY
    Homologene
    FAMILY
  • glutamine amidotransferase class-I family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • cytidine triphosphate (CTP) synthase,converting uridine triphosphate (GTP) to CTP
  • rate-limiting enzyme in de novo CTP synthesis and is required for the formation of RNA, DNA, and phospholipids
  • bifunctional member of the bacterial cytoskeleton and suggest that localization and polymerization may be important properties of metabolic enzymes
  • CTPS1 and IMPDH2, are key enzymes in CTP and GTP biosynthesis
  • specific role of CTPS1 in the immune system by its capacity to sustain the proliferation of activated lymphocytes during the immune response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism drug , purine/pyrimidine
    signaling
    last step of pyrimidine biosynthesis glycerophospholipids and nucleic acids
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacted with a GST- peptidyl prolyl isomerase, PIN1 fusion (GST-PIN1) in a Ser 575 (S575) phosphorylation-dependent manner
  • also bound tubulin
  • cell & other
    REGULATION
    Other phosphorylated by glycogen synthase kinase 3 (GSK3A and GSK3B) in response to low serum
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD24
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS