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FLASH GENE
Symbol GABRA6 contributors: - updated : 07-06-2006
HGNC name gamma-aminobutyric acid (GABA) A receptor, alpha 6
HGNC id 4080
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a ligand binding site in the N terminal region
  • four transmembrane segments (4TM), one of which forming the wall of the channel
  • a large intracellular loop
    • HOMOLOGY
    Homologene
    FAMILY ligand-gated ionic channel family
    CATEGORY signaling neurotransmitter , receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION mediating neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component component of a pentameric receptor mediating inhibitory neurotransmission
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to mood disorders
  • to schizophrenia
    • Variant & Polymorphism SNP increasing the risk of schizophrenia
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS