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FLASH GENE
Symbol HLA-DOA contributors: npt/ - updated : 19-05-2006
HGNC name major histocompatibility complex, class II, DO alpha
HGNC id 4936
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two extracellular globular domains, alpha 1, alpha2
  • a transmembrane segment
  • a cytoplasmic tail
    • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • HLA-class II family
    • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • acting as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with HLA-DOB to form HLA-DO, forming the peptide groove between alpha 1 and beta 1 domains
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HLA-DM
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS