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FLASH GENE
Symbol MUC4 contributors: np/mct - updated : 11-03-2011
HGNC name mucin 4, cell surface associated
HGNC id 7514
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • variable tandem repeat (48bp) domain
  • one cysteine residue (VNTR) in the N terminal region,giving after cleavage the two subunits MUC4A, MUC4B, MUC4- beta possessing two EGF-like domains
  • a transmembrane sequence (1TM)
  • a potential phosphorylation site
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus sialomucin
    Homologene
    FAMILY
    CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • involved in intestinal epithelial cell differentiation
  • implicated in the integrity of the renewal of the epithelium
  • potentiates neuregulin signaling by increasing the cell-surface populations of ERBB2 and ERBB3
  • function as a modulator of cell signaling and provide mechanistic evidence for its role in pancreatic cancer progression
  • plays a role in ovarian cancer cell motility, in part, by altering actin arrangement and potentiating ERRB2 downstream signalling in these cells (
  • can act as a ligand/modulator for ERBB2, affecting its localization in polarized epithelial cells and its phosphorylation
  • heterodimeric membrane mucin implicated in epithelial differentiation and tumor progression
  • undergoes proteosomal degradation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for Erb2 in cell signaling
  • target gene of ETV4 in pancreatic cancer cells (a transactivator of the MUC4 promoter through the -216 and -2368 ETV4 binding sites of the MUC4 promoter)
  • cell & other
    REGULATION
    Other regulated by TGFbeta, which represses the precursor cleavage
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic carcinoma
    tumoral     --low  
    in ovarian epithelial cancer with increased cancer stage
    tumoral     --other  
    aberrantly expressed in 75p100 of pancreatic ductal adenocarcinomas
    tumoral     --over  
    in ovarian tumors and has a role in the invasiveness of OC cells
    tumoral     --over  
    in squamous cervical dysplasia and carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • useful biological marker for the diagnosis of ductal adenocarcinomas
  • lineage marker in benign cervical tissue
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveoesophagus
    MUC1 and MUC4 may be attractive targets for the selection of treatment methods in oral squamous cell carcinoma (OSCC)
    ANIMAL & CELL MODELS