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FLASH GENE
Symbol LCOR contributors: mct - updated : 13-07-2016
HGNC name ligand dependent nuclear receptor corepressor
HGNC id 29503
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • tandem N-terminal PXDLS motifs that recruit C-terminal-binding protein (CtBP) corepressors as well as a C-terminal helix-turn-helix (HTH) domain
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    text
  • LCOR and CTBP1 colocalize in nuclear bodies
    • basic FUNCTION
  • role for LCOR and CTBP1 as attenuators of progesterone-regulated transcription, suggesting that LCOR and CTBP1 can act to enhance transcription of some genes
  • LCOR acts as an androgen-dependent corepressor that represses prostate cancer (PCa) growth
  • role of LCOR as an AR corepressor and a tumor suppressor
  • widely expressed transcriptional coregulator, LCOR, initially characterized as a regulator of nuclear receptor-mediated transactivation, functions through recruitment of C-terminal binding proteins (CtBPs) and histone deacetylases (HDACs) to its N-terminal and central domains, respectively
  • contributes to KLF6-mediated transcriptional repression in a promoter- and cell type-dependent manner
  • ZNF350 and LCOR form a transcriptional complex that silences gene expression, in particular FGF2, which maintains breast cell viability
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • LCOR and TRIM28 form a complex with ZNF350 on an intronic binding site in GADD45A gene and a novel site in the fibroblast growth factor 2 (FGF2) gene
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts directly with histone deacetylase 3 (HDAC3) and HDAC6
  • LCOR interacts with AR and is recruited to chromatin in an androgen-induced manner
  • interaction between the C-terminal domain of LCOR and the transcription factor KLF6, a putative tumor suppressor in prostate cancer
  • interaction between ligand-dependent corepressor (LCOR) and the corepressor KRAB-associated protein-1 (TRIM28)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS