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FLASH GENE
Symbol ATP1B1 contributors: mct - updated : 01-07-2014
HGNC name ATPase, Na+/K+ transporting, beta 1 polypeptide
HGNC id 804
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY family of Na+/K+ and H+/K+ ATPases beta chain proteins, subfamily of Na+/K+ -ATPases
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • osmotic balance and cell volume stability
  • non-catalytic component of the active enzyme, which catalyzes the hydrolysis of atp coupled with the exchange of na(+) and k(+) ions across the plasma membrane
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text Na+, K+ pump
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with ATP1A1 and maybe others
  • three subunits, a large catalytic subunit (alpha), a smaller glycoprotein subunit (beta), and gamma
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • binding to ATP1A1
  • through its interaction with ATP1B1, MLC1 is involved in the control of intracellular osmotic conditions and volume regulation in astrocytes, opening new perspectives for understanding the pathological mechanisms of MLC disease
  • WFS1 may be necessary for the stability of ATP6V1A and ATP1B1, but does not protect ATP6V1A and ATP1B1 from proteasome-mediated degradation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to essential hypertension
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS