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FLASH GENE
Symbol ZNF446 contributors: mct - updated : 24-11-2020
HGNC name zinc finger protein 446
HGNC id 21036
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a KRAB (Krüppel-associated box) domain, which is well documented to interact with the RBCC (RING, B-box, coiled-coil) domain of proteins within the tripartite motif (TRIM) family that in turn function as co-repressors or, as recently demonstrated, co-activators
  • three C(2)H(2) zinc fingers domains
  • a scan box domain
    • HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may be involved in transcriptional regulation
  • may act as a transcriptional repressor in mitogen-activated protein kinase (MAPK) signaling pathway to mediate cellular functions (Liu 2005)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ZNF446, and its associated tripartite motif protein, TRIM27, are obligate components of the ZNF165-SMAD3 complex that also support tumor cell viability
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ZNF446 interacts with both SMAD3 and SMAD4 in a TGFB1-dependent fashion, similar to ZNF165
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in breast tumors, an increase that trends with reduced survival in the triple-negative enriched basal-like subtype of breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS