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FLASH GENE

Symbol

GMPPA

contributors: mct - updated : 23-11-2013

HGNC name	GDP-mannose pyrophosphorylase A
HGNC id	22923

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a nucleotidyltransferase domain (AAs 3–19) shared by a wide range of enzymes that transfer nucleotides onto phosphosugars
	a hexapep domain (amino acids 286–319 likewise found in several members of the transferase families

HOMOLOGY

interspecies	homolog to murine Gmppa (97.6pc)
	homolog to rattus Gmppa (96.7pc)

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

basic FUNCTION

catalyzing the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP binding

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

AAMR

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS