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FLASH GENE
Symbol CEP63 contributors: mct/npt/pgu - updated : 29-09-2015
HGNC name centrosomal protein 63kDa
HGNC id 25815
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
text
  • centrosomal protein
  • CEP63 and CEP152 co-localize in a discrete ring around the proximal end of the parental centriole
  • basic FUNCTION
  • coordinates centrosome-dependent assembly of spindle structures
  • loss of CEP63 may contribute to the occurrence of genome instability typical of aggressive cancers
  • centrosomal recruitment factor for CDK1 essential for mitotic entry, providing a physical link between the centrosome and the cell-cycle machinery
  • CEP152 and CEP63 are essential for maintaining normal centrosome numbers in cells
  • CEP63 functions to ensure that centriole duplication occurs reliably in dividing mammalian cells
  • centrosomal protein that facilitates centriole duplication and is regulated by the DNA damage response
  • is required for maintaining normal centriole duplication and control of cell cycle progression
  • is likely particularly important for brain development and might control the proliferation and migration of cells when those two events need to be highly coordinated
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CEP63-CEP152 MCPH complex is an essential part of the molecular machinery controlling centrosome numbers
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ATM and ATR target required for normal spindle assembly
  • interacts with DISC1
  • binds to and recruits CDK1 to centrosomes, and thereby regulates mitotic entry
  • CEP63 forms a protein complex with CEP152
  • interaction between CEP63 and CEP152 can occur independently of centrosome localisation and the two proteins are dependent on one another for centrosomal localisation
  • KIAA0753 positively regulates centriole duplication and CEP63 centrosome localization
  • CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome, and they interact to promote centriole duplication
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCKL6
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in invasive bladder tumours
    constitutional       loss of function
    severely impairs meiotic recombination, leading to profound male infertility
    Susceptibility to developmental dyslexia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Cep63-deficient mice recapitulate Seckel syndrome pathology