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FLASH GENE
Symbol EXOC2 contributors: mct - updated : 08-06-2021
HGNC name exocyst complex component 2
HGNC id 24968
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • SEC5 family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text largely confined to the cytoplasm
    basic FUNCTION
  • is a downstream effector of RALA-GTPase which promotes RALA-exocyst interactions and exocyst assembly, serving to tether secretory granules to docking sites on the plasma membrane
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between DELGEF and EXOC2 was found to be dependent on Mg2+ and stimulated by guanosine triphosphate (GTP) or deoxycytidine triphosphate (dCTP)
  • RALA binding to EXOC2 “activates” the Exocyst, and subsequent binding of RALA to EXOC8 “inactivates” the Exocyst for such functions
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NEDFACH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS