SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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text
| may be accumulated at kinetochores in unaligned chromosomes in PSRC1-depleted cells to perform its gliding function |
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mitotic kinesin whose expression is up-regulated during G2 and M phases of the cell cycle, and it localizes to kinetochores from early prometaphase through metaphase moving to the antiparallel midzone MTs at anaphase |
basic FUNCTION
| kinesin-like motor protein that accumulates in the G2 phase of the cell cycle |
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required for the metaphase-anaphase transition in mitosis and meiosis II |
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may be one of the motors responsible for mammalian chromosome movement and/or spindle elongation |
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possess SUMO-2/3 polymeric chain-binding activity essential for kinetochore localization |
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implicated in powering chromosome congression by transporting mono-oriented chromosomes to the spindle equator along mature kinetochore fibers of already bioriented chromosomes |
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involved in proliferation, and aggressiveness of prolactin pituitary tumors |
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functioning as a motor that carries chromosomes toward the metaphase plate, in a manner very similar to how kinesin-1 transports vesicles |
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its enzymatic cycle is characterized by rapid ATP binding, multiple enzymatic turnovers per diffusive |
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encounter, and gating of nucleotide binding |
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functions by actively transporting chromosomes along kinetochore fibers (Rosenfeld 2009) |
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kinesin-like motor protein required for efficient capture and attachment of spindle microtubules by kinetochores, a necessary step in chromosome alignment in the metaphase plate |
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KIF2C and CENPE are involved in PSRC1-mediated chromosome congression |
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SKAP cooperates with CENPE to orchestrate dynamic kinetochore-microtubule interaction for faithful chromosome segregation |
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processive kinesin that is required for chromosome congression and stable chromosome biorientation |
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exhibits unusually slow microtubule collision coupled with slow ADP release, and this novel ATPase cycle may favor CENPE binding of stable kinetochore microtubules over dynamic microtubules |
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is vital for maintaining cell cycle and checkpoint signal mechanisms are vital for recruitment process of other essential kinetochore proteins |
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lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENPE and KIF2C |
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core kinetochore component functioning to mediate chromosome congression initially of misaligned chromosomes and in subsequent spindle microtubule capture during mitosis |
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is a highly elongated kinesin that transports pole-proximal chromosomes during congression in prometaphase |
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unexpected role of CENPE elongated stalk in ensuring stability of kinetochore-microtubule attachments during chromosome congression and segregation |
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CENPE suppresses chromosome congression, probably by tethering kinetochores to short, unstable microtubules, and works in congression only when microtubules are stabilized |
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differential contributions of KIF22 and CENPE in chromosome congression in physiological conditions where stabilized microtubules are becoming increased |
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is a microtubule plus-end-directed kinetochore motor required for congression of pole-proximal chromosomes |