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FLASH GENE
Symbol ARMC2 contributors: mct - updated : 19-03-2019
HGNC name armadillo repeat containing 2
HGNC id 23045
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 42-amino-acid motif composed of three alpha helices
    • HOMOLOGY
    interspecies ortholog to murine LOC213402
    Homologene
    FAMILY
  • ARM super-family, ARM-repeat-containing protein family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • is necessary for sperm flagellum structure and assembly, for spermatogenesis and, in particular, for sperm flagellum structure and motility
  • might be specifically involved in the central-pair complex (CPC) of microtubules assembly or stability
  • is essential for sperm-tail biogenesis and mutations in this gene lead to drastic flagellum malformations
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MMAFS2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS