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FLASH GENE
Symbol SHCBP1 contributors: mct - updated : 14-09-2021
HGNC name SHC SH2-domain binding protein 1
HGNC id 29547
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Shcbp1
Homologene
FAMILY SHC family
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
basic FUNCTION
  • despite the striking upregulation of SHCBP1 during T cell proliferation, loss of SHCBP1 does not directly affect T cell development, but regulates CD4(+) T cell effector function
  • SHCBP1 depletion promotes midbody structure disruption and inhibits abscission, a final stage of cytokinesis
  • SHCBP1 contributes to the transition from G1 to S phase in synovial sarcoma cells
  • SHCBP1 may likely be upregulated in lung cancer and it may serve a key role in the apoptosis of lung cancer cells; this effect was associated with the expression of PTEN
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SHCBP1 is a novel downstream target gene of SS18-SSX1, and the oncogene SS18-SSX1 promotes tumorigenesis by increasing the expression of SHCBP1, which normally acts as a tumor promoting factor
  • SHCBP1 promoted cell cycle progression by regulating the CDK4&
    • 8209;CCND1 cascade and suppressed CASP3, caspase PARP&
    8209;dependent apoptotic pathways
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer (GC)
    tumoral     --over  
    in lung cancer cell lines and lung cancer tissues compared with in normal lung
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may provide a potential molecular basis for the diagnosis of Gastric cancer
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    may provide a potential molecular basis for targeted therapy of GC
    ANIMAL & CELL MODELS