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FLASH GENE
Symbol EPHB1 contributors: mct/pgu - updated : 12-10-2017
HGNC name EPH receptor B1
HGNC id 3392
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a vestigial Ig-l domain
  • a single cysteine rich region
  • two FNIII domains in the extracellular region
  • a caveolin-binding motif within the kinase domain primordial for its correct membrane targeting
    • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • ephrin receptor subfamily
    • CATEGORY enzyme , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text localized in caveolae
    basic FUNCTION
  • receptor tyrosine kinase, involved in short-range contact-mediated axonal guidance
  • may be involved in cell-cell interactions in the nervous system
  • axon-guidance-pathway molecules are involved in connectivity and repair throughout life (beyond guiding brain wiring during fetal development)
  • forms a signaling complex with NCK1, paxillin, and focal adhesion kinase and induces tyrosine phosphorylation of paxillin in a c-Src-dependent manner to promote cell migration
  • recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis
  • involved in embryonic nervous and vascular system developmen
  • may have a tumor-suppressive role in gastric cancer
  • displaying unique properties that efficiently drives the uncrossed retinal projection
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to ephrin-b1, -b2 and -b3
  • interacting with TIAM1 (mediates neurite outgrowth induced by EPHB1 and EPHA2)
  • interacting with EPHB2 (induction of EPHB2 might activate EPHB1/EPHBB2 signaling pathway to regulate synaptic plasticity and reorganization)
  • interaction with EPHB2 (neural crest -derived cell-specific role of EPHB1–EPHB2 interactions in the collective migration of the thymic rudiment during organogenesis)
  • interact with E-cadherin and with the metalloproteinase ADAM10 at sites of adhesion and their activation induces shedding of CDH1 by ADAM10 at interfaces with EPHB1-expressing cells
  • RELN binds to the extracellular domains of EPHB1, EPHB2 transmembrane proteins, inducing receptor clustering and activation of EPHB forward signaling in neurons, independently of the 'classical' Reelin receptors, LRP8 and VLDLR
  • DLG3 has unique roles in cortical synapse development by mediating EPHB1 and its downstream PAK1 signaling pathway
    • cell & other
    REGULATION
    activated by ZIC2 (upregulates EPHB1 expression and define a link between a transcription factor and expression of a guidance receptor protein essential for axon guidance at the vertebrate midline)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric carcinoma associated with invasion and metastasis
    tumoral     --low  
    in poorly differentiated colorectal cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS