| basic FUNCTION
| may be required to maintain the proliferative capacity of stem cells |
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may play an important role in both tumorigenesis and transforming embryonic bone marrow mesenchymal stem cells |
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involved in the regulation of cell proliferation, and both depletion and overexpression of nucleostemin induce cell cycle arrest through the TP53 signaling pathway (Romanova 2009) |
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has a role as an integrated component of ribosome biogenesis, particularly pre-rRNA processing (Romanova 2009) |
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playing a role in ribosome biogenesis and in regulating cell proliferation (Romanova 2009) |
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has an unexpected role in post-mitotic terminal differentiation  |
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is implicated in the control of stem and cancer cell proliferation |
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potential role in tumorogenesis of brain cancers |
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maintains self-renewal of embryonic stem cells and promotes reprogramming of somatic cells to pluripotency |
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implicated in the maintenance of ESC self-renewal, demonstrating the importance of rapid transit through G1 for this process |
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primary function of nucleostemin in maintaining the genomic stability of actively dividing stem/progenitor cells by promoting the recruitment of RAD51 to stalled replication-induced DNA damage foci |
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protects HSCs from DNA damage accumulation and is required for the maintenance of HSCs |
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nucleolus residing GTPase that is considered to be an important cancer stem/progenitor cell marker protein due to its high expression levels in breast cancer stem cells and its role in tumor-initiation of human mammary tumor cells |
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nucleolar GTP-binding protein that is involved in a plethora of functions including ribosomal biogenesis and maintenance of telomere integrity |
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participates in preservation of the viability and integrity of ESCs, which is distinct from that in other GNL3-expressing cells |
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nucleolar protein with pivotal functions in maintaining genomic integrity and determining cell fates of various normal and cancerous stem cells |
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nucleolar proteins GNL2 and GNL3 have similar but non-overlapping roles in the final maturation or nucleolar release of 60S ribosomal subunits |
