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FLASH GENE

Symbol

MMD

contributors: mct - updated : 26-04-2023

HGNC name	monocyte to macrophage differentiation-associated
HGNC id	7153

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	N-terminal scaffolding domain of PAQR11 was associated with key regulators of Golgi compaction and vesicle transport
	seven potential transmembrane domains

HOMOLOGY

Homologene

FAMILY

progesterone and AdipoQ receptor family

CATEGORY

regulatory , structural protein

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,organelle,lysosome
text	MMD and MMD2 are exclusively localized in the Golgi apparatus

basic FUNCTION	acting as an ion channel protein in maturing macrophages
	EMT initiates a PAQR11-mediated Golgi compaction process that drives metastasis
	regulates monocyte-to-macrophage differentiation
	has a function in monocyte-to-macrophage differentiation and such function is related to autoimmune disease
	regulates lipolysis of adipose tissue and affects high-fat diet-induced obesity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	MMD-dependent secretion of a protease, PLAU, prevents anoikis and initiates autocrine activation of a PLAU receptor/signal transducer
	CEBPB is involved in the transcriptional regulation of the RA-related gene MMD in monocytes

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

in mice, deletion of Paqr11 gene alleviated progression of collagen-induced rheumatoid arthritis