| basic FUNCTION
| induces large vacuole formation  |
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with apoptotic cells, accumulated around the contact region during engulfment of apoptotic cells |
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epidermal growth factor repeat transmembrane protein, quiescent satellite cell marker that is also expressed in skeletal myoblasts but not in differentiated myofibers |
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represents a novel transmembrane protein that impinges on Notch signaling to regulate the satellite cell population balance between proliferation and differentiation |
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PEAR1 an engulfment receptor, and MEGF10, a purported engulfment receptor are expressed in fibroblasts, and facilitated binding to dead neurons |
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involved in the uptake of amyloid-beta peptide (Abeta42) in the brain |
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functional receptor that mediates the uptake of APP, which will help elucidate the molecular mechanisms of amlyoid-beta clearance in Alzheimer disease |
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it is possible that MEGF10 is involved in clearance of Abeta which was formed in cerebral cortex and hippocampus regions at old age |
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highly expressed in activated satellite cells and regulates their proliferation as well as their differentiation and fusion into multinucleated myofibers |
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MEGF10 and MEGF11, have critical roles in the formation of mosaics by two retinal interneuron subtypes, starburst amacrine cells and horizontal cells |
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can act as a ligand that signals to starburst amacrine cells (SACs), and horizontal cells (HCs) |
