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FLASH GENE

Symbol

ADAMTSL2

contributors: mct/npt - updated : 17/10/2008

HGNC name	ADAMTS-like 2
HGNC id	14631

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one disintegrin domain
	three TSP type-1 domains
	a signal peptide
	a thrombospondin type-1 repeat domain (TSR)
	a cysteine-rich module
	an unusually long spacer module, containing a novel insertion bearing six N-glycosylation sites
	six additional TSRs and a PLAC module

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
text	extracellular matrix

basic FUNCTION	cell-surface and extracellular matrix binding glycoprotein tha may play a role during skeletal myogenesis
	having a metalloendopeptidase activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

associate with ECM molecules through its TSR domains after secretion (Tsutsui 2010)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

GLSD1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   down-regulated in endothelial cells derived from cirrhotic liver

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS