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FLASH GENE
Symbol LRG1 contributors: SGE/npt - updated : 04-02-2010
HGNC name leucine-rich alpha-2-glycoprotein 1
HGNC id 29480
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight leucine-rich (LRR) repeats
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • LRR family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
    text secreted in the plasma
    basic FUNCTION
  • novel marker for early neutrophilic granulocyte differentiation
  • may have a role in protein-protein interaction, signal transduction, cell adhesion, development
  • may be involved in implantation/decidualization (Gillot 2008)
  • first extracellular ligand for CYC1 that has been identified (Cummings 206)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other secretory type 1 acute-phase protein whose expression is up-regulated by the mediator of acute-phase response (Shirai 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS