basic FUNCTION
| adaptor involved in the control of generation of constitutive post-Golgi carriers |
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PLEKHA3, PLEKHA8 are essential components of a PtdIns(4)P- and ARF-regulated machinery that controls generation of constitutive post-Golgi carriers |
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glucosylceramide-transfer protein that has a pivotal role in the synthesis of complex glycosphingolipids, key structural and signalling components of the plasma membrane (D'Angelo 2007) |
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confers resistance to apoptosis and may be a target for cancer therapy (Tritz 2009) |
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may be functioning directly in the formation of apical carriers in the trans-Golgi network |
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having membrane tubulation activity, that requires a functionally intact PH domain that can bind to PI (4)P |
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adaptor protein of phosphatidylinositol-4-phosphate and is involved in the transport of some apical cargos from the trans-Golgi network (TGN) (Yui 2009) |
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necessary to generate AQP2-bearing vesicles at trans-Golgi that will undergo phosphorylation by PKA in subapical regions (Yui 2009) |
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protein that localizes dynamically with the trans-Golgi network and regulates the transport of proteins from the Golgi complex to the cell surface |
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role for FAPP2 as lipid transfer protein involved in glycosphingolipid metabolism at the Golgi complex |
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plays a key role in glycosphingolipid (GSL) production using its C-terminal domain to transport newly synthesized glucosylceramide away from the cytosol-facing glucosylceramide synthase in the cis-Golgi for further anabolic processing |