Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PLEKHA8 contributors: mct - updated : 03-12-2014
HGNC name pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
HGNC id 30037
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal pleckstrin homology (PH) domain recognizing the Golgi marker, phosphatidylinositol 4-phosphate [PI (4)P]
  • a central proline-rich region
  • a glycolipid transfer protein (GLTP)–like domain toward the C terminus (Cao 2009)
  • mono polymer dimer
    HOMOLOGY
    interspecies homolog to murine Plekha8 (91.3pc)
    homolog to rattus Plekha8 (90.6pc)
    Homologene
    FAMILY
  • pleckstrin homology domain-containing family A
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • failed to localize at the TGN and was present mainly in the Golgi cisternae in cells
  • basic FUNCTION
  • adaptor involved in the control of generation of constitutive post-Golgi carriers
  • PLEKHA3, PLEKHA8 are essential components of a PtdIns(4)P- and ARF-regulated machinery that controls generation of constitutive post-Golgi carriers
  • glucosylceramide-transfer protein that has a pivotal role in the synthesis of complex glycosphingolipids, key structural and signalling components of the plasma membrane (D'Angelo 2007)
  • confers resistance to apoptosis and may be a target for cancer therapy (Tritz 2009)
  • may be functioning directly in the formation of apical carriers in the trans-Golgi network
  • having membrane tubulation activity, that requires a functionally intact PH domain that can bind to PI (4)P
  • adaptor protein of phosphatidylinositol-4-phosphate and is involved in the transport of some apical cargos from the trans-Golgi network (TGN) (Yui 2009)
  • necessary to generate AQP2-bearing vesicles at trans-Golgi that will undergo phosphorylation by PKA in subapical regions (Yui 2009)
  • protein that localizes dynamically with the trans-Golgi network and regulates the transport of proteins from the Golgi complex to the cell surface
  • role for FAPP2 as lipid transfer protein involved in glycosphingolipid metabolism at the Golgi complex
  • plays a key role in glycosphingolipid (GSL) production using its C-terminal domain to transport newly synthesized glucosylceramide away from the cytosol-facing glucosylceramide synthase in the cis-Golgi for further anabolic processing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text glycolipid transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of a phosphatidyl-inositol-4-phosphate and ADP-ribosylation factor regulated machinery that controls generation of constitutive post-Golgi carriers
  • INTERACTION
    DNA
    RNA
    small molecule other,
  • interacting with phosphatidyl-inositol-4-phosphate
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS