basic FUNCTION
| promoting homologous chromosome pairing and meiotic double-strand break repair |
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with PSMC3IP, are indispensable for meiotic recombination (Chi 2007) |
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PSMC3IP1/MND1 stabilizes the RAD51-single-stranded DNA (ssDNA) nucleoprotein filament, the catalytic intermediate in recombination reactions (Chi 2007) |
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PSMC3IP-MND1 stabilizes the DMC1-single-stranded DNA (ssDNA) filament and promotes the capture of the double-stranded DNA partner by the recombinase filament to assemble the synaptic complex |
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PSMC3IP-MND1 is a 'molecular trigger' of RAD51 DNA strand exchange |
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RAD51 and the PSMC3IP-MND1 heterodimer, are essential for homologous chromosome synapsis during meiosis |
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PSMC3IP/MND1 is expressed in somatic tissues, primary human fibroblasts and cell lines, and that it functions in conjunction with the RAD51 recombinase to repair damaged telomeres via the alternate lengthening of telomeres mechanism |