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FLASH GENE
Symbol MND1 contributors: npt/ - updated : 25-10-2016
HGNC name meiotic nuclear divisions 1 homolog (S. cerevisiae)
HGNC id 24839
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • MND1 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text localizes to chromatin throughout meiotic prophase
    basic FUNCTION
  • promoting homologous chromosome pairing and meiotic double-strand break repair
  • with PSMC3IP, are indispensable for meiotic recombination (Chi 2007)
  • PSMC3IP1/MND1 stabilizes the RAD51-single-stranded DNA (ssDNA) nucleoprotein filament, the catalytic intermediate in recombination reactions (Chi 2007)
  • PSMC3IP-MND1 stabilizes the DMC1-single-stranded DNA (ssDNA) filament and promotes the capture of the double-stranded DNA partner by the recombinase filament to assemble the synaptic complex
  • PSMC3IP-MND1 is a 'molecular trigger' of RAD51 DNA strand exchange
  • RAD51 and the PSMC3IP-MND1 heterodimer, are essential for homologous chromosome synapsis during meiosis
  • PSMC3IP/MND1 is expressed in somatic tissues, primary human fibroblasts and cell lines, and that it functions in conjunction with the RAD51 recombinase to repair damaged telomeres via the alternate lengthening of telomeres mechanism
  • CELLULAR PROCESS nucleotide, repair, base excision repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the multicatalytic proteinase complex
  • part of PSMC3IP/MND1 complex that may ensure proper pairing between homologous chromosomes through its stimulation of strand exchange during meiosis (Enomoto 2006)
  • evolutionarily conserved PSMC3IP/MND1 complex is a key cofactor for the meiosis-specific recombinase DMC1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PSMC3IP-MND1 induces changes in the conformation of RAD51 that profoundly alter the basic properties of RAD51
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS