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FLASH GENE
Symbol IRF2BP2 contributors: mct/npt/pgu - updated : 18-05-2009
HGNC name interferon regulatory factor 2 binding protein 2
HGNC id 21729
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal zinc finger
  • a phosphorylation-dependent nuclear localization motif (
  • a C-terminal RING finger domain of the C3HC4 type
    • HOMOLOGY
    Homologene
    FAMILY
  • IRF2BP family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • found in the nucleus of cardiac and skeletal muscle cells (nuclear localization of IRF2BP2 depends on phosphorylation near a conserved NLS)
    • basic FUNCTION
  • corepressor for IRF2
  • can inhibit both enhancer-ativated and basal transcription in an IRF2-dependent manner
  • might be part of a new feedback-loop for the cells after p53 activation, increasing the threshold for induction of apoptosis, but also inhibiting the progression of cell cycle, possibly to allow repair of damaged DNA
  • required to activate VEGFA expression
  • ischemia-induced coactivator of VEGFA expression that may contribute to revascularization of ischemic cardiac and skeletal muscles
  • represses the NFATC2-dependent transactivation of NFAT-responsive promoters
  • negative regulator of the NFATC2 transcription factor, suggesting that NFATC2 repression occurs at the transcriptional level
  • muscle-enriched transcription factor required to activate vascular endothelial growth factor-A (VEGFA) expression in muscle
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with IRF2
  • direct target gene of TP53, influencing the TP53-mediated cellular decision (promotes cell-cycle arrest and seems to interfere with TP53-mediated apoptosis after chemotherapeutic treatment)
  • cellular target of ITGB3BP, identified as a transcriptional repressor
  • interaction of IRF2BP2, IRF2BP1, and EAP1 occurs through the conserved C4 zinc fingers of these proteins, and forms DIF-1 complex
  • specifically interacts with the C-terminal domain of NFATC2 among the NFAT family members
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS