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FLASH GENE
Symbol ZBTB2 contributors: SGE/npt - updated : 17-08-2009
HGNC name zinc finger and BTB domain containing 2
HGNC id 20868
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a BTB/POZ domain
  • four C2H2-type zinc fingers
    • HOMOLOGY
    interspecies homolog to murine Zbtb2 (94.7pc)
    homolog to rattus Zbtb2 (94.7pc)
    Homologene
    FAMILY
  • POK family transcription factor
    • CATEGORY regulatory , transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be involved in regulation of transcription
  • proto-oncogenic master control gene of the TP53 pathway: potent transcription repressor of the cell cycle arrest gene CDKN1A by inhibiting TP53 and SP1, stimulating cell proliferation (Jeon 2009)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • ion Zn2+
    • protein
  • directly interacting with TP53 and SP1 (Jeon 2009)
    • cell & other
    REGULATION
    Other phosphorylated upon DNA damage, probably by ATM or ATR
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS