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FLASH GENE
Symbol MTCH1 contributors: mct - updated : 27-11-2010
HGNC name mitochondrial carrier homolog 1 (C. elegans)
HGNC id 17586
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PDZ-like domain and several protein kinase C and tyrosine phosphorylation sites, PDZ domain and N-terminal fragment are required for the pro-apoptotic activity
  • a mitochondrial carrier domain conserved in several inner membrane carriers, which partially overlaps one of the predicted transmembrane segments
  • multiple mitochondrial targeting motifs dispersed along the protein but that a transmembrane domain in the correct position and orientation is necessary for membrane insertion
  • HOMOLOGY
    interspecies homolog to murine Mtch1
    Homologene
    FAMILY
  • mitochondrial carrier family
  • CATEGORY regulatory , transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    text integral mitochondrial outer membrane protein
    basic FUNCTION
  • positive regulator of apoptosis
  • induces cytochrome c release, independtly of caspase activation
  • mitochondrial apoptotic protein
  • apoptosis induced by MTCH1 likely involves the permeability transition pore
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • presenilin 1-associated protein, interacting with the C terminus of PSEN1
  • in addition to APAF1 or apoptosome formation, DIABLO is also essential for MTCH1-induced apoptosis
  • both the formation of cytochrome c-APAF1 apoptosome and the presence of DIABLO are absolutely required for MTCH1-induced apoptosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS