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FLASH GENE
Symbol DHRS4 contributors: mct - updated : 23-05-2011
HGNC name dehydrogenase/reductase (SDR family) member 4
HGNC id 16985
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
SDR motif
mono polymer homomer , tetramer
HOMOLOGY
interspecies homolog to murine Dhrs4
Homologene
FAMILY short chain dehydrogenase/reductase (SDR) family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,peroxisome
intracellular,nucleus
basic FUNCTION
  • reduces all trans-retinal and 9-cis-retinal
  • can catalyze the oxidation of trans-retinol with NADP as cofactor
  • reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings
  • may inhibit cell replication either by catalyzing the oxidation of estrogen and androgen, or by converting cortisone in cortisol
  • NADP(H)-dependent retinol oxidoreductase participating in the metabolism of retinoids
  • reduced various aromatic ketones and alpha-dicarbonyl compounds including cytotoxic 9,10-phenanthrenequinone (
  • role of the inducible DHRS4 in 3beta-hydroxysteroid synthesis and xenobiotic carbonyl metabolism
  • reduces all-trans-retinal and xenobiotic carbonyl compounds
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by kaempferol, quercetin, genistein and myristic acid
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS