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FLASH GENE
Symbol ALG3 contributors: npt/mct - updated : 28-02-2024
HGNC name asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog (S. cerevisiae)
HGNC id 23056
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • multiple membrane-spanning helices
  • a C-terminal (KKXX) endoplasmic reticulum retrieval signal
    • HOMOLOGY
    interspecies ortholog to S.cerevisiae alg3
    ortholog to murine Alg3
    ortholog to rattus alg3_predicted
    Homologene
    FAMILY
  • ALG3 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • catalysing the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol
  • PPFIA1 and ALG3 may play roles in oncogene expression in in head and neck squamous cell carcinoma (HNSCC)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HSF2 activated ALG3 and promoted the growth of breast carcinoma
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1D
    related resource Congenital Disorder of Glycosylation pages
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    expressed higher in bladder cancer than that in the normal tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential biomarker for the prognosis of Bladder Cancer
    • Therapy target
    ANIMAL & CELL MODELS