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FLASH GENE
Symbol TFRC contributors: mct/npt/pgu - updated : 10-09-2017
HGNC name transferrin receptor (p90, CD71)
HGNC id 11763
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • TFRC-N-Terminal fragment that is subject to regulated intramembrane proteolysis
  • a protease associated (PA) domain
  • an M28 peptidase domain
  • a transferrin receptor-like dimerization domain
  • conjugated GlycoP , LipoP , PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Tfrc (76.5 pc)
    homolog to murine Tfrc (77.3 pc)
    Homologene
    FAMILY
  • peptidase M28 family
  • M28B subfamily
  • CATEGORY receptor , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • associated with HEF in crypt cells, type 2 membrane protein
  • cytoplasmic membrane-bound vesicle
  • single-pass type II membrane protein
  • basic FUNCTION
  • playing a necessary role for development of erythrocytes and the nervous system
  • involved in the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes
  • required for c-Myc-mediated cellular proliferation and cell size control
  • its inhibition decreases cellular proliferation and results in G1 arrest without affecting cell size, and alters expression of genes that regulate the cell cycle
  • mitochondrial biogenesis orchestrated by PPRGC1B, coupled with iron uptake through TFRC and iron supply to mitochondrial respiratory proteins, is a fundamental pathway linked to osteoclast activation and bone metabolism
  • is a mitochondrial regulator
  • facilitates cellular iron uptake through receptor-mediated endocytosis of iron-loaded transferrin
  • implicated in homeostatic maintenance of the intestinal epithelium, acting through a role that is independent of its iron-uptake function
  • importance of TFRC in adaptive immunity
  • important iron transporter regulating iron homeostasis that has long been used as a marker for clathrin mediated endocytosis
  • function in iron transport
  • transferrin-bound iron is known to be delivered to cells by TFRC after internalization via clathrin-mediated endocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport
    text
  • iron homeostasis
  • iron ion transport
  • PATHWAY
    metabolism
    signaling
    a component
  • homodimer disulfide-linked
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding one transferrin or HFE molecule per subunit
  • binding to the HLA class II histocompatibility antigen, DR1
  • interacting with SH3BP3
  • critical downstream target of c-Myc
  • interacting with WWC1 (although suppression of WWC1 and dynein perturbs early endosome-to-endocytic recycling compartment transport, TFRC sorting is maintained
  • interacting with TF through a loop in the N-lobe of serum transferrin that is critical for binding to the transferrin receptor
  • important receptor for FTH1
  • critical role for RBSN in determining the fate of TFRC internalized by clathrin-mediated endocytosis
  • new function for TFRC in the control of IKK and NFKB1
  • SPPL2A, and mainly SPPL2B are responsible for the intramembrane proteolysis of TFRC-N-terminal fragment
  • TFRC has an important role in SPHK1-mediated oncogenesis
  • TXLNA interacts with SNX4 and plays a role in the recycling pathway of TFRC
  • STEAP3, a metalloreductase expressed in erythroblasts, associates with TFRC and partially rescues transferrin uptake
  • functions as a regulator to control AMPA receptor trafficking efficiency and synaptic plasticity
  • role of EGFR in modulating cellular iron homeostasis through redistribution of TFRC, which is essential for cancer development and progression
  • cell & other
    REGULATION
    Other regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3 prime-UTR
    up-regulated upon mitogenic stimulation
    its levels are regulated by cellular iron levels
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD46
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in hepatoma cells due to a combination of iron deficiency and chemical hypoxia
    tumoral     --over  
    highly expressed in glioblastomas and associated with shorter survival (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • it can be reliably used as an independent erythroid marker for immunohistochemical analysis of the marrow
  • Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerative 
    drugs that increase TFRC palmitoylation, are possible therapeutic approaches in the treatment of NBIA and also in more common neurodegenerative disorders, including Parkinson disease, where brain iron accumulation is also reported
    bloodhemoglobin 
    erythroid-progenitor-targeted gene therapy using bifunctional TFRC Ligand-Peptides in erythropoietic protoporphyria
    ANIMAL & CELL MODELS
  • mice lacking Tfr1 in the heart died in the second week of life and had cardiomegaly, poor cardiac function, failure of mitochondrial respiration, and ineffective mitophagy