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FLASH GENE
Symbol JOSD1 contributors: mct - updated : 26-06-2013
HGNC name Josephin domain containing 1
HGNC id 28953
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one Josephin domain
    • HOMOLOGY
    interspecies homolog to murine Josd1 (97.0pc)
    homolog to rattus Josd1 (97.0pc)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • preferentially localizes to the plasma membrane, particularly when ubiquitinated
    • basic FUNCTION
  • cleaves ubiquitin chains only after it is monoubiquitinated, a form of posttranslational-dependent regulation shared with ATXN3
  • could potentially participate in membrane-dependent events such as cell motility and endocytosis
  • membrane-associated deubiquitinating enzyme whose activity is regulated by ubiquitination, helps regulate membrane dynamics, cell motility, and endocytosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activate NR5A1 gene expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS