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FLASH GENE
Symbol IGHV4-39 contributors: - updated : 04-11-2005
HGNC name immunoglobulin heavy variable 4-39
HGNC id 5651
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a sequence of some 110 aminoacids folded to form a compact immunoglobulin domain with both ends joined together by a disulfide bond
  • made of three hypervariable regions (complementary-determining regions) located on the N terminal part of the sequence
  • the remaining part being relatively constant and forming the framework
    • HOMOLOGY
    Homologene
    FAMILY Immunoglobulin superfamily
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • forming the antigen binding site together with the cognate region of the light chain
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text humoral immunity, antibody synthesis
    PATHWAY
    metabolism
    signaling
    a component
  • component of the immunoglobulin molecules which are tetramers of two identical heavy chains and two identicallight chains, either kappa or lambda, bound by disulfide bonds
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C-terminal end covalently bound to the DJ segment by the V(D)J recombination system (see RAG1, RAG2)
  • during the process, a random loss or gain of nucleotides occurs (junctional diversification)
  • bound by a disulfide bond to a variable light chain
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS