Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RBSN contributors: mct - updated : 14-09-2017
HGNC name rabenosyn, RAB effector
HGNC id 20759
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • EEA1 and Rabenosyn-5 contain a distinctive N-terminal C(2)H(2) zinc finger that binds RAB5
  • a FYVE finger domain
  • a novel sequence required for its interaction with VPS45
    • HOMOLOGY
    interspecies homolog to Drosophila CG8506
    homolog to yeast S.cerevisiae Vac1p
    homolog to murine Zfyve20
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • acting sequentially with EHD1 in the transport of proteins from early endosomes to the endosomal recycling compartement and back to the plasma membrane
  • serving as a molecular link between VPS45 and the Rab5 GTPase
  • ZFYVE20 and EHD1 may act sequentially in the transport of proteins from early endosomes to the endosomal recycling compartment and back to the plasma membrane
  • RBSN is a RAB5 effector that bridges an interaction between Rab5 and the Sec1/Munc18-family protein VPS45
  • VPS45 interacts with ZFYVE20 and carries out multiple functions in the endocytic/secretory pathways
  • VPS45 and ZFYVE20 are implicated in post early endosome transport, and their interaction potentially serves as a nexus to promote bidirectional transport along the endosome-to-recycling compartment and endosome-to-Golgi axes
  • EEA1 and ZFYVE20 facilitate endosome tethering, sorting, and fusion
  • regulates endocytosis at the apical side of the wing epithelium and, surprisingly, further uncovered a novel function of this protein in planar cell polarity (PCP)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text endosome transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ions Zn2+ binding
    protein
  • interacting with RAB5
  • VPS45 interacts with RBSN and carries out multiple functions in the endocytic/secretory pathways
  • interaction between EEA1 and Rabenosyn-5 (RBSN), which facilitate endosome tethering, sorting, and fusion
  • critical role for RBSN in determining the fate of TFRC internalized by clathrin-mediated endocytosis
    • cell & other
    REGULATION
    Other recruited in a phosphatidylinositol-3-kinase-dependent fashion to early endosomes
    MAPK14 can phosphorylate the RAB5 effectors EEA1 and ZFYVE20 on Thr-1392 and Ser-215, respectively, and these phosphorylation events regulate the recruitment of EEA1 and ZFYVE20 to membranes
    ASSOCIATED DISORDERS
    corresponding disease(s) RBSND
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS