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FLASH GENE
Symbol IKZF2 contributors: mct - updated : 29-08-2013
HGNC name IKAROS family zinc finger 2 (Helios)
HGNC id 13177
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four N terminal zinc fingers comprising the DNA binding domain
  • two C terminal zinc fingers mediating dimerization
  • six C2H2-type zinc fingers
    • conjugated MetalloP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Zfpn1a2
    Homologene
    FAMILY
  • zinc finger subfamily 1A
  • IKAROS family of zinc-finger proteins
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • differentiation of lymphocytes
  • involved in regulation of transcription, DNA-dependent
  • central role in T cell development and homeostasis, but it is not essential for T cells, and its function can be compensated for by other members of the Ikaros family
  • Ikaros family members are critical for a functional immune system that confers protection against invading pathogens, while minimising the risk of leukaemic transformation, immune pathology, and autoimmunity
  • IKZF2 expression is associated with T cell activation and cellular division
  • key regulator of IL2 expression in Tregs, contributing to the maintenance of the anergic phenotype
  • is the first marker known to diverge during positive and negative selection of thymocytes
  • IKZF2 and SATB1, are considered to be important in proper Treg development
    • CELLULAR PROCESS cell life, differentiation
    nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • integral component of chromatin-remodeling complexes
  • homo or heterodimerizing with either other member of the family
    • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • up-regulate expression of FOXP3 protein, whereas SATB1 is known to inhibit its expression (
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of the short transcript in T cell acute lymphoblastic leukemia
    tumoral   translocation    
    t(2;14)(q34;q32) (fusion of BCL11B and IKZF2) in adult T-cell leukemia/lymphoma (ATLL)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS