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FLASH GENE
Symbol SLC2A12 contributors: mct - updated : 18-03-2020
HGNC name solute carrier family 2 (facilitated glucose transporter), member 12
HGNC id 18067
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • SLC2A8 and SLC2A12 both contain a similar [DE]XXXL[LI] dileucine sorting signal in their N- terminus
    • HOMOLOGY
    Homologene
    FAMILY
  • sugar transporter family, glucose transporter subfamily
  • facilitative family of glucose transporters
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nuclear envelope
    text
  • is located in the apical cytoplasm, below the brush border membrane, and in the perinuclear region of human enterocytes
    • basic FUNCTION
  • insulin-regulated facilitative sugar transporter
  • dispensable for embryonic development but influences hippocampal neurogenesis and heart function
  • in contrast to SLC2A4, insulin does not mediate SLC2A12 translocation, which may function as a basal GLUT located primarily at the cell surface in the myocardium
  • evidence for SLC2A9 and SLC2A12 expression in vascular smooth muscle cells (VSMCs) in conjunction with the previously identified SLC2A1 and SLC2A10
  • SLC2A12 activity is voltage dependent
  • plays a critical role in the model of breast cancer progression through high glucose concentrations
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC2A8 regulates enterocyte fructose transport by regulating SLC2A12, and disrupted SLC2A8 function has deleterious long-term metabolic sequelae
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS