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FLASH GENE
Symbol ADAM7 contributors: mct - updated : 10-04-2012
HGNC name ADAM metallopeptidase domain 7
HGNC id 214
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one disintegrin domain
    • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Adam7
    Homologene
    FAMILY
  • peptidase family M12B
  • ADAM (a disintegrin and metalloprotease domain) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text
  • type 1 membrane protein
  • ADAM7 and ITM2B are located in detergent-resistant regions known to be highly correlated with membrane lipid rafts
    • basic FUNCTION
  • non catalytic metalloprotease-like protein playing an important role in male reproduction including sperm maturation and gonadotrope function
  • transferred from the epididymis to the sperm surface and redistributed in the sperm head during acrosome reaction
  • can be transferred directly from epididymal vesicles to sperm and that it is an integral plasma membrane protein in sperm
  • functions in fertilization through the formation of a chaperone complex and enhanced association with ITM2B during capacitation in sperm
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ADAM7 forms complexes with calnexin (CANX), heat shock protein 5 (HSPA5), and integral membrane protein 2B (ITM2B)
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • association of ADAM7 with ITM2B is remarkably promoted during sperm capacitation owing to a conformational change of ADAM7 that occurs in concert with the capacitation process (
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    often mutated in melanoma, and could play a role in melanoma progression (Pubmed 21618342)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS