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FLASH GENE
Symbol ATPAF1 contributors: mct - updated : 22-12-2010
HGNC name ATP synthase mitochondrial F1 complex assembly factor 1
HGNC id 18803
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a consensus sequence PXFXXXLPR
    • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae,assembly of the F1 component of the mitochondrial ATPase
    intraspecies paralog to ATPAF2
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • with ATPAF2, are proteins required for the assembly of beta (F(1)-beta) and alpha (F(1)-alpha) subunits into the mitochondrial ATPase
  • required for the F1 assembly, preserved in all eukaryotic lineages that are capable of ATP synthesis via oxidative phosphorylation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to F1 alpha subunits
  • interacting with OGFOD1 through OGFOD1 iron binding residues that are required for ATPAF1 gene expression
    • cell & other
    REGULATION
    Other regulated by OGFOD1 (ATPAF1 mRNA expression required the activity of OGFOD1 P4H domain rather than OGFOD1 protein expression levels)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS