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FLASH GENE
Symbol ATP8B3 contributors: mct - updated : 29-06-2021
HGNC name ATPase, Class I, type 8B, member 3
HGNC id 13535
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • cation transport ATPases family (E1-E2 ATPases), subfamily IV
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • ATP8B3 did not bind CDC50A and CDC50B and was invariably present in the ER
  • exclusively expressed in the testis and its expression is likely developmentally regulated during testicular development
    • basic FUNCTION
  • aminophospholipid translocase ATP8B3
  • potential phospholipid-transporting
  • may play a role in acrosome development and/or in sperm function during fertilization
  • potential role for ATP8B3 in sperm cell capacitation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ATP8B3 has an ATPase activity and is phosphorylated by an ATP-producing acylphosphate intermediate, which is a signature property of the P-Type ATPases
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS