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FLASH GENE

Symbol

ST3GAL3

contributors: mct/ - updated : 19-11-2013

HGNC name	ST3 beta-galactoside alpha-2,3-sialyltransferase 3
HGNC id	10866

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	sialyl motifs L, S, and VS, (L and S previously demonstrated their involvement in the binding of donor and acceptor substrates)
	region comprised between the sialyl motifs S and VS contains a stretch of four highly conserved residues, with the following consensus sequence (H/y)Y(Y/F/W/h)(E/D/q/g)
	four N-glycan attachment sites in its catalytic domain that are potentially glycosylated (N-glycosylation appears to contribute to the proper folding and trafficking of the enzyme)

conjugated

GlycoP

isoforms

Precursor

the soluble form derives from the transmembrane form by proteolytic processing

HOMOLOGY

interspecies

homolog to murine Siat6

Homologene

FAMILY

vertebrate sialyltransferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type II membrane protein
	membrane-bound form in tran-cisternae of Golgi
	soluble form in body fluids

basic FUNCTION	transfering sialic acid to terminal positions on the carbohydrate groups of glycoproteins and glycolipids
	being key determinants for a variety of cellular recognition processes
	sialyltransferase involved in the biosynthesis of sialyl-Lewis epitopes on cell surface-expressed glycoproteins

CELLULAR PROCESS

protein, post translation

PHYSIOLOGICAL PROCESS

text	glycosylation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

plays an important role in SIGLEC5 ligand formation and eosinophil apoptosis with resultant effects on eosinophilic inflammation in the lung

cell & other

REGULATION

Other

regulated by all-trans-retinoic acid (RA) (RA is a significant regulator of GALM and other galactose-related genes in myeloid-monocytic cells, which could affect energy utilization and synthesis of cell-surface glycoproteins or glycolipids involved in cell motility, adhesion, and/or functional properties)

ASSOCIATED DISORDERS

corresponding disease(s)

EIEE15 , NSMR5

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in the pancreatic adenocarcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

ST3Gal-III heterozygote mice (deficient in expression of Siglec-F ligands) also had significantly enhanced OVA(OVA allergen)-induced eosinophilic airway inflammation associated with reduced eosinophil apoptosis