Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PSMA1 contributors: mct - updated : 12-07-2022
HGNC name proteasome (prosome, macropain) subunit, alpha type, 1
HGNC id 9530
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Psma1
Homologene
FAMILY peptidase family T1A
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway
  • exhibits endoribonuclease activity controlled by extra-cellular stimuli
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component 20 S (prosome-macropain) of multicatalytic proteinase complex of proteasome
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in fertilization failure (FF), occurring in intracytoplasmic sperm injection (ICSI) cycles
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS