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FLASH GENE
Symbol ZC3HAV1 contributors: mct - updated : 10-01-2018
HGNC name zinc finger CCCH type, antiviral 1
HGNC id 23721
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • lacks the structural requirements for ADP-ribosyltransferase activity
    • HOMOLOGY
    interspecies homolog to rattus Zap
    homolog to murine Zc3hav1
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • is an RNA-binding protein that regulates the stability and translation of specific mRNAs, and modulates the miRNA silencing pathway to globally affect miRNA targets
  • these functions of ZC3HAV1 are important components of the cellular response to stress
  • likely inhibits the retrotransposition of LINE and Alu elements
  • association of the ZC3HAV1 ribonucleoprotein particle with many interferon-stimulated gene products indicates it may be a key player in the interferon response
  • is a host factor that specifically inhibits the replication of certain viruses by binding to viral mRNAs and repressing the translation and/or promoting the degradation of target mRNA
  • is a host antiviral factor that specifically inhibits the replication of certain viruses, including HIV-1, Sindbis virus, and Ebola virus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binds directly to specific viral mRNAs and recruits cellular mRNA degradation machinery to degrade the target RNA
    small molecule
    protein
  • is a key regulator of DDX58 signaling during the innate antiviral immune response
  • DHX30 is required for optimal antiviral activity of ZC3HAV1
  • function for MATR3 as a negative regulator of the ZC3HAV1-mediated restriction of retroviruses
  • TRIM25 is a bona fide ZC3HAV1 cofactor that leads to increased ZC3HAV1 modification enhancing its translational inhibition activity
  • TRIM25, a ubiquitin E3 ligase, is required for the antiviral activity of ZC3HAV1
    • cell & other
    REGULATION
    Phosphorylated by by glycogen synthase kinase 3beta (GSK3B)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS